The treatment of small bowel overgrowth (SIBO) is usually carried out in several steps: First, the bacterial overgrowth is reduced with the help of antibiotics such as rifaximin or herbal remedies (e.g. oregano oil or berberine). At the same time, diet plays a key role – many patients benefit from a low-FODMAP diet or a specific carbohydrate diet. Supporting intestinal motility and the targeted development of intestinal flora with probiotics and prebiotics are also important components of therapy. The aim is not only to relieve symptoms in the short term, but also to stabilize intestinal health in the long term.